Researchers identify Alzheimer’s tipping point: Excess glycation (i.e. too much sugar)

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Alzheimer’s and Sugar

For the first time a “tipping point” molecular link between the blood sugar glucose and Alzheimer’s disease has been established by scientists, who have shown that excess glucose damages a vital enzyme involved with inflammation response to the early stages of Alzheimer’s.

Abnormally high blood sugar levels, or hyperglycaemia, is well-known as a characteristic of diabetes and obesity, but its link to Alzheimer’s disease is less familiar.

Diabetes patients have an increased risk of developing Alzheimer’s disease compared to healthy individuals. In Alzheimer’s disease abnormal proteins aggregate to form plaques and tangles in the brain which progressively damage the brain and lead to severe cognitive decline.

Scientists already knew that glucose and its break-down products can damage proteins in cells via a reaction called glycation but the specific molecular link between glucose and Alzheimer’s was not understood.

But now scientists from the University of Bath Departments of Biology and Biochemistry, Chemistry and Pharmacy and Pharmacology, working with colleagues at the Wolfson Centre for Age Related Diseases, King’s College London, have unraveled that link.

By studying brain samples from people with and without Alzheimer’s using a sensitive technique to detect glycation, the team discovered that in the early stages of Alzheimer’s glycation damages an enzyme called MIF (macrophage migration inhibitory factor) which plays a role in immune response and insulin regulation.

MIF is involved in the response of brain cells called glia to the build-up of abnormal proteins in the brain during Alzheimer’s disease, and the researchers believe that inhibition and reduction of MIF activity caused by glycation could be the ‘tipping point’ in disease progression. It appears that as Alzheimer’s progresses, glycation of these enzymes increases.

The study was published in the journal Scientific Reports.

More Than Just the Mind

Professor Jean van den Elsen, from the University of Bath Department of Biology and Biochemistry, said:

“We’ve shown that this enzyme is already modified by glucose in the brains of individuals at the early stages of Alzheimer’s disease. We are now investigating if we can detect similar changes in blood.

“Normally MIF would be part of the immune response to the build-up of abnormal proteins in the brain, and we think that because sugar damage reduces some MIF functions and completely inhibits others that this could be a tipping point that allows Alzheimer’s to develop.

Dr Rob Williams, also from the Department of Biology and Biochemistry, added:

“Knowing this will be vital to developing a chronology of how Alzheimer’s progresses and we hope will help us identify those at risk of Alzheimer’s and lead to new treatments or ways to prevent the disease.

Dr Omar Kassaar, from the University of Bath, added:

“Excess sugar is well known to be bad for us when it comes to diabetes and obesity, but this potential link with Alzheimer’s disease is yet another reason that we should be controlling our sugar intake in our diets.”

Globally there are around 50 million people with Alzheimer’s disease, and this figure is predicted to rise to more than 125 million by 2050. The global social cost of the disease runs into the hundreds of billions of dollars as alongside medical care patients require social care because of the cognitive effects of the disease.

The study was funded by the Dunhill Medical Trust. Human brain tissue for this study was provided through Brains for Dementia Research, a joint initiative between Alzheimer’s Society and Alzheimer’s Research UK in association with the Medical Research Council.

Comment: Despite the defeatist tone in the video above, excess glycation which leads to Alzheimer’s can be prevented with a low carbohydrate diet.

See also: Sugar and your brain: Is Alzheimer’s disease actually type 3 diabetes?

 
 

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Aspartame Corporation Searle Created First Birth Control Pill: American Eugenics and Big Pharma, a History.

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Did you know that Aspartame producing corporation Searle also manufactured the first birth control pill?

After Donald Rumsfeld was Secretary of Defense under Gerald Ford, he was the CEO of Searle, engineering their merger with Monsanto. A testament to his influence, he became Secretary of Defense again during the Bush Administration, participating in atrocious torture and war crimes such as the ones at Abu Ghraib.

One of the most veracious proponents for forced sterilization of blacks, the poor, and “imbeciles,” Planned Parenthood founder Margaret Sanger, was a main contributor to what would culminate into Searle’s manufacture of “Enovid”: the first hormonal birth control pill. This philosophy is commonly known as “eugenics,” sometimes referred to as “dysgenics” or “epi-eugenics.”

Well summarized by the Embryo Project:

Enovid was the first hormonal birth control pill. G.D. Searle and Company began marketing Enovid as a contraceptive in 1960. The technology was created by the joint efforts of many individuals and organizations, including Margaret Sanger, Katharine McCormick, Gregory Pincus, John Rock, Syntex, S.A. Laboratories, and G.D. Searle and Company Laboratories. Although there were many pieces and contributors to the final product, it was first conceived of and created by Gregory Pincus and Margaret Sanger through the Worcester Foundation in Worcester, Massachusetts, and was distributed by Searle, located in Chicago.”

To illustrate historical ties between “big pharma” and eugenics, let’s take a look at the legacy of Dr. John Hurty, an early chemist at Prozac producer Eli Lilly and Company in the 1870’s.

Hurty would go on to influence the passage of the United States’ first mandatory sterilization law, in 1907 Indiana.

He was a tireless eugenicist, who believed that the poor, colored people, the disabled, ect. were a burden to the state and society, unfit for reproduction, and should be sterilized.

Upwards of 60,000 Americans were involuntarily sterilized through to even the 1970’s, while Dr. John Hurty, Margaret Sanger, David Starr Jordan and others made major contributions. Reading from an article by renowned author Edwin Black:

“Ultimately, eugenics practitioners coercively sterilized some 60,000 Americans, barred the marriage of thousands, forcibly segregated thousands in “colonies,” and persecuted untold numbers in ways we are just learning.”

Dr. John Hurty, first president of Stanford David Starr Jordan, and Margaret Sanger were members of the scientific, academic class which birthed eugenics, and eventually the world we live in today where Searle had a hand in both birth control, and suspicious toxins such as Aspartame.

Reading from this document, which is based on the 1946 book The Hoosier Health Officer: A Biography of Dr. John N. Hurty“:

“In 1873, John Newell Hurty went to work for Col. Eli Lilly in his newly established Eli Lilly and Company Pharmaceuticals in Indianapolis as his chief chemist.  Then in 1879, Hurty opened his own drug store at the corner of Ohio and Pennsylvania streets.  In the basement of that establishment, he set up one of the first analytical laboratories in the state.  Among the variety of things he tested for purity was water for the Indianapolis Water Company.

In 1884, Dr. Hurty established, and for a time taught at, the School of Pharmacy at Purdue University.  In 1891, Hurty earned his medical degree from the Medical College of Indiana.   

In 1899, Dr. Hurty wrote a bill that became the first comprehensive food and drug legislation to be enacted in the United States.  It was not only used as a model by other states, but the Federal Law of 1906 is taken almost word for word from Dr. Hurty’s bill.”

This article/video seeks to pose the question: was birth control created as part of eugenics, population control, as part of something that goes beyond money or some alleged philanthropic agenda? Are certain chemicals or pharmaceuticals in circulation designed to fulfill an agenda that goes beyond money, an agenda perhaps that extends into eugenics?

We are not suggesting people do one thing or another with their bodies, we are not asking you to make a decision about your health, but we are presenting you with historical info to better make decisions for yourself.

We’re making the case that Searle profited from the eugenic ambitions of people such as Margaret Sanger: while it is unclear at this moment whether Searle cared about simply money or something deeper. This should raise suspicion about why they pushed so hard for the legalization of Aspartame after the FDA had already banned it, under the direction of powerful Donald Rumsfeld.

Given all of this history, we would be wise to ask: could Aspartame possibly have roots in eugenics? Could certain pharmaceutical drugs have ties to eugenics? It is not a wild accusation or unreasonable question to ponder.

To take it even further: FDA commissioner Margaret Hamburg is the daughter of not one, but two directors of the American Eugenics Society, which later was quietly renamed the “The Society for Biodemography and Social Biology.”

By: Cassius Kamarampi

Sources:

eraofwisdom.org/aspartame-turns-into-formaldehyde-and-methanol-in-the-body-donald-rumsfeld-got-it-legalized/

youtube.com/watch?v=bHSRwhceBxk

dailysignal.com/2015/07/22/13-things-you-probably-dont-know-about-planned-parenthood-founder-margaret-sanger/

youtube.com/watch?v=QOmRk26jrNo

embryo.asu.edu/pages/enovid-first-hormonal-birth-control-pill

wikipedia.org/wiki/G.D._Searle,_LLC

globalresearch.ca/donald-rumsfeld-the-war-crimes-case/3841

indianapublicmedia.org/momentofindianahistory/reform-indianas-eugenics-crusader/

sfgate.com/opinion/article/Eugenics-and-the-Nazis-the-California-2549771.php

youtube.com/watch?v=jaljxOe554M

sourcewatch.org/index.php/Eli_Lilly

amazon.com/Hoosier-Health-Officer-Biography-Hurty/dp/B0000D5N6H

eraofwisdom.org/fda-commissioners-parents-led-eugenics-society-father-was-carnegie-president-population-control-and-poison/

scribd.com/doc/97130973/American-eugenics-society-1945-2012

scribd.com/doc/22768234/Names-Social-Biology-Revision-1

wikipedia.org/wiki/David_Starr_Jordan

embryo.asu.edu/pages/david-starr-jordan-1851-1931

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Turmeric-Carrot-Black Pepper Soup Fights, Alzheimer’s, Inflammation & Cancer.

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Turmeric contains active compounds with powerful medicinal properties and these compounds are called curcuminoids, the most important of which is Curcumin. One study found that when even 2g of curcumin was ingested, its serum levels were very low. However, when 20mg piperine compound found in black pepper was added to curcumin the bioavailability increased by 2000%. Curcumin provides high levels of antioxidant protection – 13 times higher than Blueberries.

It offer numerous health benefits since they are powerful antioxidant, anti-inflammatory, antiseptic, anti-fungal, anti-bacterial agents.

Turmeric May Help Combat Alzheimer’s Disease and Inflammatory Conditions

Curcumin is capable of crossing your blood-brain barrier, which is one factor that has led researchers to investigate its potential as a neuroprotective agent for neurological disorders such as Parkinson’s and Alzheimer’s disease.

Another common condition that can benefit from curcumin’s anti-inflammatory activity is osteoarthritis. Research16 published in 2011 found that patients who added 200 mg of curcumin a day to their treatment plan had reduced pain and increased mobility.

Curcumin is non-toxic, and does not adversely affect healthy cells, suggesting it selectively targets cancer cells.

Turmeric-Carrot-Black Pepper Soup Recipe

Moroccan Carrot Soup

Ingredients:

2 tablespoons butter
2 teaspoons turmeric
1 1/2 teaspoons cumin seeds
1 tablespoon honey
1 tablespoon fresh lemon juice
1/8 teaspoon allspice
1 cup chopped organic yellow onion
1 pound large organic carrots, cut in ½- inch dice (about 2 ⅔ cups)
2 1/2 cups low-sodium organic chicken stock or vegetable stock
2 minced garlic cloves (or more to taste)
Salt and fresh cracked black pepper (to taste)
1/2 cup sour cream, crème fraishe, or plain yogurt, optional for garnish

Preparation:

Melt butter in a large sauce pan over medium-high heat and add onion; saute for 2 minutes.
Mix in carrots and broth. Bring to boil.
Reduce heat, cover and simmer until carrots are very tender, about 20 minutes.
Stir cumin seeds in a small skillet over medium-high heat until fragrant, about 4 – 5 minutes.
Finely grind in a spice mill and remove soup from heat. Puree in batches in a blender until smooth.
Return to sauce pan. Whisk in honey, lemon juice and allspice.
Season with salt and pepper. Ladle soup into bowl.
Sprinkle with toasted cumin, or mix cumin and sour cream in a small bowl and dollop on top.
Serve.

Sources:

foodista

drweil

draxe

healthy-holistic-living

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Some deodorants could cause breast cancer: Swiss study.

Women who regularly use deodorants containing aluminium salts could risk developing breast cancer, a new Swiss study warns.

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Initial tests on isolated mammary cells derived from a normal human gland were later replicated in studies on mice, and the results were the same: long-term exposure to concentrations of aluminium caused cells to form tumours and metastasise.

“I think we should avoid all deodorants containing aluminium salts,” co-author André-Pascal Sappino told The Local.

“And it’s very difficult to be sure that the so-called ‘without aluminium’ brands really are without,” added the oncology professor from the University of Geneva.

Sappino said the team’s earlier research was treated with scepticism, but mounting evidence meant it was much easier to get published this time.

For now, aluminium salts were a “suspect, not yet convicted”, said the professor, who drew an analogy with asbestos, the use of which is banned in Switzerland and the European Union.

“Asbestos is cheap, has very attractive industrial potential, and it took 50 years to ban it. We hope it doesn’t take so long to ban aluminium salts,” said Sappino.

Like asbestos, aluminium is not detectably mutagenic in bacteria, but subcutaneous injections of aluminium salts in mice resulted in “very aggressive tumours”.

While the study has not completely established a formal link with breast cancer, Sappino said he would advise all women against using deodorants that contain aluminium salts.

Men too should think twice: while breast cancer among men is rare, its incidence is rising, Sappino said.

The oncologist said he fully expected to face resistance from the cosmetics industry.

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“Now the fight will begin. They will act like the tobacco industry and say that proof in human beings is lacking.”

Sappino said he expected that team’s finding would make it easier to secure funding to further examine the cancer-causing effects of aluminium salts.

The study, co-authored by four researchers from the Clinique des Grangettes, is published in the International Journal of Cancer.

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“HIV Virus” Detected In Walmart Bananas After 10 Year Old Boy Contracts The Virus.

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A 10-year-old boy who had eaten a banana his mother purchased at a Walmart in Tulsa, Oklahoma, was rushed to the emergency room due to fever, chills and fatigue just seven days after consumption. After a thorough examination, blood tests and scans the young boy tested positive for the HIV virus. His mother obviously in shock. However, the 10-year-old child was not the only one admitted to the hospital for the same issue. Eight children, all under the age of 17, have been diagnosed as HIV-positive within the month of March. What is the one thing they have in common? Purchasing bananas from The Tulsa, Oklahoma Walmart.

According to the parents, they submitted several foods their children had been eating to doctors for testing, along with documenting the different places they had visited within the month. They found that all 8 children had consumed bananas from the superstore. The facility, LHC Laboratories, tested the bananas which all came up positive containing the HIV virus. Researchers are still trying to understand how the virus could have entered the bananas, stayed active, and infected the children through consumption.

In the meantime, bananas are being pulled off the shelves in Walmart stores across the United States. According to many media outlets, the CDC is encouraging Americans to discard any uneaten bananas and to contact your doctor if you experience any of the following symptoms:

  •  Fever
  •  Chills
  •  Rash
  •  Night sweats
  •  Muscle aches
  •  Sore throat
  •  Fatigue
  •  Swollen lymph nodes
  •  Mouth sores

These symptoms could be an indication that you have contracted the HIV virus and need to seek medical attention immediately.

Source: cnnews3

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